Correlation between carbohydrate, protein and fat intake with serum c-reactive protein level in lung cancer patients stage IIIB-IV

Patricia Amanda, Diana Sunardi, Noorwati Sutandyo

Abstract


Introduction: The aim of the study is to determine the correlation between carbohydrate, fat and protein intake with the serum C-Reactive Protein level in lung cancer patients stage IIIB IV. The progression of lung cancer is influenced by immune system, genetic factors and inflammatory response, therefore CRP can be relied as one of the parameters for predicting cancer cell growth.
Methods: The research with cross sectional design was conducted in Dharmais Cancer Hospital Jakarta. Subjects were recruited by consecutive sampling, 49 subjects with lung cancer stage IIIB- IV who currently not receving any treatment in Dharmais Hospital participating in this study A total of 49 subjects with lung cancer stage IIIB- IV who currently not receving any treatment were taken using consecutive sampling method.
Results: The mean age of subject was 55,82 + 12,26 years old and 63,3% were male. The median value of CRP is 23,82 (0,30 - 207,29) mg/L.
Conclusion: This study did not showed significant correlation between carbohydate, protein and fat intake with serum CRP level (p = 0,919; p = 0,257; p = 0,986, respectively). But on additional analysis we did found that there was a negative, non significant correlation between protein intake and serum CRP level in cancer patient stage IV, as well as fat intake and serum CRP level.


Keywords


C-Reactive Protein, inflammation, lung cancer, carbohydrate intake, protein intake and fat intake.

References


GLOBOCAN. Estimated cancer incidence, mortality and prevalance worldwide in 2012, International Agency for Research on Cancer, World Health Organization 2012. http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx (accessed 4 October 2016).

Komite Nasional Penanggulangan Kanker (KPKN). Panduan nasional penanganan kanker paru. Kementerian Kesehatan Republik Indonesia, 2015.

Santarpia L, Contaldo F, Pasanisi F. Nutritional screening and early treatment of malnutrition in cancer patients. J Cachexia Sarcopenia Muscle 2011;2:2735

Ross PJ, Ashley S, Norton A, Priest K, Waters JS, Eisen T, et al (2004) Do patients with weight loss have a worse outcome when undergoing chemotherapy for lung cancers? Br J Cancer 2004;90(10):19051911

Van Cutsem E, Arends J. The causes and consequences of cancer-associated malnutrition. Eur J Oncol Nurs 2005:9;S51S63

Balkwill FR, Capasso M, Hagemann T. The tumor microenvironment at a glance. J Cell Sci 2012;135:559196.

Beloribi-Djefaflia S, Vasseur S, Guillaumond F. Lipid metabolic reprogramming in cancer cells. Oncsis 2016;5:189.

Warburg O, Wind F, Negelein E. The metabolism of tumors in the body. J Gen Physiol 1927;8:519-30.

Djiogue S, Kamdje AHN, Vecchio L, Maulilio JK, Farahna M, Aldebasi Y, et al. Insulin resistance and cancer: the role of insulin and IGFs. Endocr Relat Cancer 2013;20:R1R17.

Donohoe CL, Ryan AM, Reynolds J V. Cancer cachexia : mechanisms and clinical implications. Gastroentral Res Pract 2011; 2011:601434.

Porporato PE. Understanding cachexia as a cancer metabolic syndrome. Oncsis 2016;5:e200.

Lieberman M, Marks AD, Peet A. Carbohydate Metabolism. In: Marks Basic Medical Biochemistry A Clinical Approach 4th edition. Philadelphia: Lippincott Williams & Wilkins; 2013. p. 473-582.

Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011.

Roxburgh CSD, McMillan DC. Role of systemic inflammatory response in predicting survival in patients with primary operable cancer. Future Oncol 2010;6(1):149163.

Fontana L, Klein S, Holloszy JO. Long-term low-protein, low-calorie diet and endurance exercise modulate metabolic factors associated with cancer risk. Am J Clin Nutr 2006;84: 145662.

Freedland SJ, Mavropoulos J, Wang A, Darshan M, Demark-Wahnefried W, et al. Carbohydrate restriction, prostate cancer growth, and the insulin-like growth factor axis. Prostate 2008;68:1119.

Madiyono B, Moeslichan S, Sastroasmoro S, Budiman I, Purwanto SH. Perkiraan besar sampel. Dalam: Sastroasmoro S, Ismael S, editor. Dasar-dasar metodologi penelitian klinis. Edisi ke-4. Jakarta: Sagung Seto 2011;34881.

Sutandyo N. Epidemiological data and survival of lung cancer in Indonesia. Dharmais cancer hospital, Indonesia, 2015.

Alberg AJ, Brock MV, Ford JG, Samet JM, Spivack SD. Epidemiology of lung cancer. Chest 2015;143(5): e1se29s.

Sanchez-Lara K, Turcott JG, Juarez E, Guevara P, Nunez-Valencia C. Association of nutritional parameters including bioelectrical impedance and systemic inflammatory response with quality of life and prognosis in patients with advanced non-small-cell lung cancer: a prospective study. Nutr Cancer 2012;64:52634.

Perhimpunan Dokter Paru Indonesia. Kanker paru pedoman diagnosis & penatalaksanaan di Indonesia. Edition 2015. Jakarta, Markindo Anugerah Citra Pratama, 2016.

Hutton JL, Baracos VE, Wismer WV. Chemosensory dysfunction is a primary factor in the evolution of declining nutritional status and quality of life in patients with advanced cancer. J Pain Symptom Manage 2007;33:156165.

Ho VW, Leung K, Hsu A, Luk B, Lai J, Shen SY, et al. A low carbohydrate, high protein diet slows tumor growth and prevents cancer initiation. Cancer Res 2011;71(13):448493.

Gomes de Lima KV, Maio R. Nutritional Status, systemic inflammation and prognosis of patients with gastrointestinal cancer. Nutr Hosp. 2012; 27(3): 70714.

Stobaus N, Muller MJ, Kupferling S, Schulzke J, Norman K. Low recent protein intake predicts cancer-related fatigue and increased mortality in patients with advanced tumor disease undergoing chemotherapy. Nutr Cancer 2015;67(5):81824.

Heikkila K, Ebrahim S, Lawlor DA. A systematic review of the association between circulating concentration of C reactive protein and cancer. J Epidemiol Community Health 2007; 61: 824832.

Pepys MB, Hirschfield GM. C-reactive protein: a critical update. J Clin Invest 2003; 111:18051812.




DOI: https://doi.org/10.25220/WNJ.V01i2.0006

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