Nutritional Status Influences High-Molecular Weight (HMW) Adiponectin levels in Breast Cancer Patients: Comparison with Healthy Controls

Abd Rashid Ainaa Almardhiyah, Zahali Zunura’in, Venkata Murali Krishna Bhavaraju, Siew Hua Gan, Abdullah Sarimah, Syed Abdullah Sharifah Zahhura, Jan Mohamed Hamid Jan

Abstract


Introduction: Breast cancer is the leading killer of women in Malaysia. Nutritional status and adiponectin are modifiable risk factors for breast cancer occurrence which can be efficiently targeted. The purpose of this study was to determine the relationship between nutritional status and high molecular weight (HMW) adiponectin levels among breast cancer patients as compared to controls. Methods: This was a case- control study, conducted in Hospital Universiti Sains Malaysia and Universiti Sains Malaysia campus. Newly diagnosed breast cancer cases (n=55) were assigned as cases while healthy controls (n=58) were staff members of HUSM and USM campus. Sociodemographic and reproductive data were obtained with a standard questionnaire while the dietary data was obtained from a validated diet history questionnaire. Anthropometric assessments [weight, height, hip, waist circumference (WC) and body fat composition] were measured while overnight fasting venous blood samples were analysed for lipid profiles, glucose, insulin, high sensitivity C-reactive protein and HMW adiponectin. Results: A significant linear negative relationship exists between WC and HMW adiponectin (β=-0.05; p=0.005) among breast cancer cases. Additionally, HDL cholesterol was positively associated with HMW adiponectin (β=1.83; p=0.010) among the cases. BMI was negatively associated with HMW adiponectin (β=-0.02; p=0.001) among healthy controls. Conclusion: Our findings suggest that WC, BMI and HDL cholesterol had significant relationship with HMW adiponectin. Low levels of HMW adiponectin, low WC and high HDL levels may be protective against breast cancer

Keywords


Nutritional status; high-molecular weight adiponectin; waist circumference; body mass index; high density lipoprotein cholesterol; breast cancer

Full Text:

PDF

References


--

Forouzanfar MH, Foreman KJ, Delossantos AM, Lozano R, Lopez AD, Murray CJ, et al. Breast and cervical cancer in 187 countries between 1980 and 2010: a systematic analysis. The lancet 2011 Oct;378(9801):1461-84. [Google Scholar]

Basen-Engquist K, Chang M. Obesity and cancer risk: recent review and evidence. Current oncology reports 2011 Feb;13(1):71-6. [Google Scholar]

Institute for Public Health. (2015). National of Health and Morbidity Survey 2015 Volumn II Non-Communicable Disease, Risk Factors & Other Health Problems. Malaysia: Institute for Public Health, Ministry of Health

Shakersain B, Santoni G, Faxen-Irving G, Rizzuto D, Fratiglioni L, Xu W. Nutritional status and survival among old adults: an 11-year population-based longitudinal study. European journal of clinical nutrition 2016;70(3):320. [Google Scholar]

Bechard LJ, Duggan C, Touger-Decker R, Parrott JS, Rothpletz-Puglia P, Byham-Gray L, et al. Nutritional status based on body mass index is associated with morbidity and mortality in mechanically ventilated critically ill children in the PICU. Critical care medicine 2016;44(8):1530. [Google Scholar]

Jeejeebhoy KN, Detsky AS, Baker JP. Assessment of nutritional status. Journal of Parenteral and Enteral Nutrition 1990;14:193. [Google Scholar]

American Cancer Society. (2016). Cancer Prevention & Early Detection, Facts & Figures: 2015-2016. Retrieved from https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/cancer-prevention-and-early-detection-facts-and-figures/cancer-prevention-and-early-detection-facts-and-figures-2015-2016.pdf

Bail, J., Meneses, K., & Demark-Wahnefried, W. (2016). Nutritional status and diet in cancer prevention. Paper presented at the Seminars in Oncology Nursing.

Sahran, N. F., Harith, S., & Mohamed, R. (2016). Prevalence of geriatric malnutrition and its associated factors at the Hospital Universiti Sains Malaysia, Kelantan. Malaysian journal of nutrition, 22(1), 41-53.

Coelho M, Oliveira T, Fernandes R. State of the art paper Biochemistry of adipose tissue: an endocrine organ. Archives of Medical Science 2013 Mar;9(2):191-200. [Google Scholar]

Ronti T, Lupattelli G, Mannarino E. The endocrine function of adipose tissue: an update. Clinical endocrinology 2006;64(4):355-65. [Google Scholar]

Zhu N, Pankow JS, Ballantyne CM, Couper D, Hoogeveen RC, Pereira M, et al. High-molecular-weight adiponectin and the risk of type 2 diabetes in the ARIC study. The Journal of Clinical Endocrinology & Metabolism 2010 Nov;95(11):5097-104. [Google Scholar]

Waki H, Yamauchi T, Kamon J, Kita S, Ito Y, Hada Y, et al. Generation of globular fragment of adiponectin by leukocyte elastase secreted by monocytic cell line THP-1. Endocrinology 2005 Feb;146(2):790-6. [Google Scholar]

Arita Y, Kihara S, Ouchi N, Maeda K, Kuriyama H, Okamoto Y, et al. Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB–binding protein and regulates growth factor–induced common postreceptor signal in vascular smooth muscle cell. Circulation 2002 Jun;105(24):2893-8. [Google Scholar]

Ye R, Scherer PE. Adiponectin, driver or passenger on the road to insulin sensitivity. Molecular metabolism 2013 Aug;2(3):133-41. [Google Scholar]

Katira A, Tan PH. Adiponectin and its receptor signaling: an anti-cancer therapeutic target and its implications for anti-tumor immunity. Expert opinion on therapeutic targets 2015 Aug;19(8):1105-25. [Google Scholar]

Shahar S, Salleh RM, Ghazali AR, Koon PB, Mohamud WN. Roles of adiposity, lifetime physical activity and serum adiponectin in occurrence of breast cancer among Malaysian women in Klang Valley. Asian Pac J Cancer Prev 2010 Jan;11(1):61. [Google Scholar]

Fuhrman BJ, Freedman DM, Bhatti P, Doody MM, Fu YP, Chang SC, et al. Sunlight, polymorphisms of vitamin D-related genes and risk of breast cancer. Anticancer research 2013 Feb;33(2):543-51. [Google Scholar]

Trieu PD, Mello-Thoms C, Peat JK, Do TD, Brennan PC. Risk Factors of Female Breast Cancer in Vietnam: A Case-Control Study. Cancer research and treatment: Official journal of Korean Cancer Association 2017;49(4):990. [Google Scholar]

Norlaili AA, Fatihah MA, Daliana NF, Maznah D. Breast Cancer Awareness of Rural Women in Malaysia: is it the Same as in the Cities. Asian Pacific Journal of Cancer Prevention 2013;14(12):7161-4. [Google Scholar]

Yip CH, Bhoo PN, Teo S. A review of breast cancer research in Malaysia. Med J Malaysia 2014;69(suppl A):8-22. [Google Scholar]

Abdullah A, Abdullah KL, Yip CH, Teo SH, Taib NA, Ng CJ. The decision-making journey of Malaysian women with early breast cancer: A qualitative study. Asian Pacific Journal of Cancer Prevention 2013;14(12):7143-7. [Google Scholar]

Boucher BA, Wanigaratne S, Harris SA, Cotterchio M. Postdiagnosis Isoflavone and Lignan Intake in Newly Diagnosed Breast Cancer Patients: Cross-Sectional Survey Shows Considerable Intake from Previously Unassessed High-Lignan Foods. Current Developments in Nutrition 2017 Dec;2(3). [Google Scholar]

Vetto JT, Luoh SW, Naik A. Breast cancer in premenopausal women. Current problems in surgery 2009 Dec;46(12):944-1004. [Google Scholar]

Strumylaite, L., Kregzdyte, R., Poskiene, L., Bogusevicius, A., Pranys, D., & Norkute, R. (2017). Association between lifetime exposure to passive smoking and risk of breast cancer subtypes defined by hormone receptor status among non-smoking Caucasian women. PLoS ONE, 12(2), e0171198. doi:10.1371/journal.pone.0171198

Ahl S, Guenther M, Zhao S, James R, Marks J, Szabo A, et al. Adiponectin levels differentiate metabolically healthy vs unhealthy among obese and nonobese white individuals. The Journal of Clinical Endocrinology & Metabolism 2015 Nov;100(11):4172-80. [Google Scholar]

Guenther M, James R, Marks J, Zhao S, Szabo A, Kidambi S. Adiposity distribution influences circulating adiponectin levels. Translational Research 2014 Oct;164(4):270-7. [Google Scholar]

Amadou A, Ferrari P, Muwonge R, Moskal A, Biessy C, Romieu I, et al. Overweight, obesity and risk of premenopausal breast cancer according to ethnicity: a systematic review and dose‐response meta‐analysis. Obesity Reviews 2013;14(8):665-78. [Google Scholar]

Huang Z, Hankinson SE, Colditz GA, Stampfer MJ, Hunter DJ, Manson JE, et al. Dual effects of weight and weight gain on breast cancer risk. Jama 1997 Nov;278(17):1407-11. [Google Scholar]

Booth A, Magnuson A, Fouts J, Foster M. Adipose tissue, obesity and adipokines: role in cancer promotion. Hormone molecular biology and clinical investigation 2015 Jan;21(1):57-74. [Google Scholar]

Nakanishi K, Nishida M, Yamamoto R, Koseki M, Moriyama T, Yamauchi-Takihara K. Association between N-terminal pro-brain natriuretic peptide and adiponectin in healthy Japanese men. Clinica Chimica Acta 2016 Sep;460:138-41. [Google Scholar]

Pointer, M. A., Bridges, L., Wells, C., Bolin, D., & Greene, N. (2015). Abstract P240: Gender Differences in the Association of Adiponectin and BMI in a Rural Cohort of African Americans. Hypertension, 66(Suppl 1), AP240-AP240.

Botella-Carretero JI, Balsa JA, Gomez-Martin JM, Peromingo R, Huerta L, Carrasco M, et al. Circulating free testosterone in obese men after bariatric surgery increases in parallel with insulin sensitivity. Journal of endocrinological investigation 2013 Apr;36(4):227-32. [Google Scholar]

Xu A, Chan KW, Hoo RL, Wang Y, Tan KC, Zhang J, et al. Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes. Journal of Biological Chemistry 2005 May;280(18):18073-80. [Google Scholar]

Duggan C, Irwin ML, Xiao L, Henderson KD, Smith AW, Baumgartner RN, et al. Associations of insulin resistance and adiponectin with mortality in women with breast cancer. Journal of Clinical Oncology 2011 Jan;29(1):32. [Google Scholar]

Bianco A, Nigro E, Monaco ML, Matera MG, Scudiero O, Mazzarella G, et al. The burden of obesity in asthma and COPD: Role of adiponectin. Pulmonary pharmacology & therapeutics 2017 Apr;43:20-5. [Google Scholar]

Tomoda K, Yoshikawa M, Itoh T, Tamaki S, Fukuoka A, Komeda K, et al. Elevated circulating plasma adiponectin in underweight patients with COPD. Chest 2007 Jul;132(1):135-40. [Google Scholar]

Wei EK, Giovannucci E, Fuchs CS, Willett WC, Mantzoros CS. Low plasma adiponectin levels and risk of colorectal cancer in men: a prospective study. Journal of the National Cancer Institute 2005 Nov;97(22):1688-94. [Google Scholar]

Abbenhardt C, McTiernan A, Alfano CM, Wener MH, Campbell KL, Duggan C, et al. Effects of individual and combined dietary weight loss and exercise interventions in postmenopausal women on adiponectin and leptin levels. Journal of internal medicine 2013;274(2):163-75. [Google Scholar]

Winsz‐Szczotka K, Kuźnik‐Trocha K, Komosińska‐Vassev K, Kucharz E, Kotulska A, Olczyk K. Relationship between adiponectin, leptin, IGF‐1 and total lipid peroxides plasma concentrations in patients with systemic sclerosis: possible role in disease development. International journal of rheumatic diseases 2016;19(7):706-14. [Google Scholar]

Falahi E, Rad AH, Roosta S. What is the best biomarker for metabolic syndrome diagnosis. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 2015 Oct;9(4):366-72. [Google Scholar]

Wen, S.-Y., Tamilselvi, S., Shen, C.-Y., Day, C. H., Chun, L.-C., Cheng, L.-Y., Ou, H.-C., Chen, R.-J., Viswanadha, V. P., Kuo, W.-W. (2017). Protective effect of HDL on NADPH oxidase-derived super oxide anion mediates hypoxia-induced cardiomyocyte apoptosis. PLoS ONE, 12(6), e0179492.

Hao G, Li W, Guo R, Yang JG, Wang Y, Tian Y, et al. Serum total adiponectin level and the risk of cardiovascular disease in general population: A meta-analysis of 17 prospective studies. Atherosclerosis 2013 May;228(1):29-35. [Google Scholar]

Rothenbacher D, Brenner H, März W, Koenig W. Adiponectin, risk of coronary heart disease and correlations with cardiovascular risk markers. European Heart Journal 2005 Jun;26(16):1640-6. [Google Scholar]

Maser RE, Lenhard MJ, Pohlig RT, Balagopal PB. Pre-heparin lipoprotein lipase mass as a potential mediator in the association between adiponectin and HDL-cholesterol in type 2 diabetes. Journal of clinical & translational endocrinology 2017 Mar;7:7-11. [Google Scholar]

Lu CW, Yh, Lo , Chen CH, Lin CY, Tsai CH, Chen PJ, et al. VLDL and LDL, but not HDL, promote breast cancer cell proliferation, metastasis and angiogenesis. Cancer letters 2017 Mar;388:130-8. [Google Scholar]

Furberg AS, Veierød MB, Wilsgaard T, Bernstein L, Thune I. Serum high-density lipoprotein cholesterol, metabolic profile, and breast cancer risk. Journal of the National Cancer Institute 2004 Aug;96(15):1152-60. [Google Scholar]

Assiri A, Kamel HF, Hassanien MF. . Resistin, visfatin, adiponectin, and leptin: risk of breast cancer in pre-and postmenopausal saudi females and their possible diagnostic and predictive implications as novel biomarkers. Disease markers. 2015; 2015. [Google Scholar]

--




DOI: https://doi.org/10.25220/WNJ.V02.i2.0004

Refbacks

  • There are currently no refbacks.


Copyright (c) 2019 Ainaa Almardhiyah Abd Rashid, Zunura’in Zahali, Venkata Murali Krishna Bhavaraju, Hua Siew Gan, Sarimah Abdullah, Sharifah Zahhura Syed Abdullah, Hamid Jan Jan Mohamed

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.