Association of Serum Adiponectin Levels with Metabolic Syndrome Risk Factors in Malay Adults

Nur Firdaus Isa, Laila Ruwaida Mohd Zainuddin, Wan Manan Wan Muda, Hamid Jan B. Jan Mohamed

Abstract


Introduction: This study aimed to investigate the relationship between serum adiponectin and metabolic syndrome in adults living in rural Malaysia.

Methods: A total of 299 Malay adults (men=124; women = 175) with a mean age 48.8 (11.7) years were recruited. Measurements for waist circumference and blood pressure were taken before drawing an overnight fasting blood samples. Biochemical tests for triglycerides, HDL cholesterol, glucose and serum adiponectin concentration were measured.

Results: Our results show that the adiponectin level in the subjects with metabolic syndrome was significantly lower than those without metabolic syndrome (p < 0.05). Among the metabolic syndrome risk factors, adiponectin level was significantly associated with hypertriglyceridemia and reduced HDL cholesterol (p < 0.001).

Conclusion: The outcome from this study which highlights the association of hypoadiponectinemia with risk factors of metabolic syndrome in Malay adults, suggests that the reduced level of adiponectin may play a pivotal role in the development of metabolic syndrome in this ethnic group.


Keywords


adipokines, metabolic syndrome, obesity, dyslipidaemia, Asian

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DOI: https://doi.org/10.25220/WNJ.V01i1.0005

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Copyright (c) 2017 Isa N.F, Zainuddin L.R.M, Wan Muda W.M, Jan Mohamed H.J.B

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