Selenium in Hyperthyroidism
Abstract
Introduction: Thyroid gland has the highest selenium content compare with other endocrine organs. Enzyme that catalyzing thyroid hormone activation, iodothyronine deiodinases, were identified as selenocysteine-containing proteins. Selenium levels in soil and rice consumed in Indonesia were lower than in several other countries, which can increase the risk of selenium deficiency.Methods: This is an article review of the current literatures published up to November 2018 about the role of selenium in hyperthyroid.Result: Several studies have shown that selenium supplementation can be beneficial in patients with Graves disease and autoimmune thyroiditis. Selenium has an important immunomodulatory effect, but the effects of selenium supplementation in hyperthyroid has not been conclude. Data regarding selenium intake, prevalence of deficiency, and the relationship between selenium and thyroid disease in Indonesia are limited. Various studies of selenium supplementation in thyroid disease provide controversial results, so there are no guidelines that include selenium as standard therapy hyperthyroid. Selenium supplementation can enhance the restoration of biochemical euthyroidism in Graves disease and was associated with a significant decrease in the levels of thyroid peroxidase antibodies in autoimmune thyroiditis.Conclusions: Micronutrients that play a role in thyroid hormone synthesis and maintain thyroid function in addition to selenium are iodine, iron, zinc, and vitamin A. By correcting the deficit of selenium, and meeting other micronutrient requirements may provide health benefits in patient with hyperthyroid.Downloads
References
Ross DS, Burch HB, Cooper DS, Greenlee MC, Laurberg P, Maia AL, et al. 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis. Thyroid 2016;26:1343-421. [Google Scholar]
Balitbang Kemenkes R. Riset Kesehatan Dasar; RISKESDAS. Jakarta: Balitbang Kemenkes RI 2013.
Das S, Bhansali A, Dutta P, Aggarwal A, Bansal M, Garg D, et al. Persistence of goitre in the post-iodization phase: micronutrient deficiency or thyroid autoimmunity. The Indian journal of medical research 2011;133:103. [Google Scholar]
Köhrle J. Pathophysiological relevance of selenium. Journal of endocrinological investigation 2013;36:1-7. [Google Scholar]
Kohrle J. Selenium and the thyroid. Curr Opin Endocrinol Diabetes Obes 2015;22:392-401. [Google Scholar]
Holik HA, Bianti H, Mutakin RA. Determination of selenium concentration in different species of rice consumed in Bandung Indonesia. Int Res J Pharm App Sci 2013;3:38-41. [Google Scholar]
Rivai IF, Setiawan A, Abdulah R, Kobayashi K, Yamazaki C, Kameo S, et al. A Study of the association between selenium and cardiovascular disease in Lampung, Indonesia. Southeast Asian Journal of Tropical Medicine and Public Health 2016;47:299. [Google Scholar]
Sharma R, Bharti S, Kumar KH. Diet and thyroid-myths and facts. Journal of Medical Nutrition and Nutraceuticals 2014;3:60. [Google Scholar]
Zheng H, Wei J, Wang L, Wang Q, Zhao J, Chen S, et al. . Effects of Selenium Supplementation on Graves’ Disease: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine 2018; 2018. [Google Scholar]
Nacamulli D, Mian C, Petricca D, Lazzarotto F, Barollo S, Pozza D, et al. Influence of physiological dietary selenium supplementation on the natural course of autoimmune thyroiditis. Clinical endocrinology 2010;73:535-9. [Google Scholar]
Kahaly GJ, Riedl M, König J, Diana T, Schomburg L. Double-blind, placebo-controlled, randomized trial of selenium in graves hyperthyroidism. The Journal of Clinical Endocrinology & Metabolism 2017;102:4333-41. [Google Scholar]
Taylor PN, Albrecht D, Scholz A, Gutierrez-Buey G, Lazarus JH, Dayan CM, et al. Global epidemiology of hyperthyroidism and hypothyroidism. Nat Rev Endocrinol 2018;14:301-16. [Google Scholar]
Kravets I. Hyperthyroidism: diagnosis and treatment. Am Fam Physician 2016;93:363-70. [Google Scholar]
Smith TJ, Hegedüs L. Graves’ disease. New England Journal of Medicine 2016;375:1552-65. [Google Scholar]
Pearce EN, Farwell AP, Braverman LE. Thyroiditis. New England Journal of Medicine 2003;348:2646-55. [Google Scholar]
Carney LA, Quinlan JD, West JM. Thyroid disease in pregnancy. American family physician 2014;89.
Duntas LH, Benvenga S. Selenium: an element for life. Endocrine 2015;48:756-75. [Google Scholar]
Ventura M, Melo M, Carrilho F. . Selenium and thyroid disease: From pathophysiology to treatment. International journal of endocrinology 2017; 2017. [Google Scholar]
Thiry C, Ruttens A, Pussemier L, Schneider YJ. An in vitro investigation of species-dependent intestinal transport of selenium and the impact of this process on selenium bioavailability. British Journal of Nutrition 2013;109:2126-34. [Google Scholar]
Gammelgaard B, Rasmussen LH, Gabel-Jensen C, Steffansen B. Estimating intestinal absorption of inorganic and organic selenium compounds by in vitro flux and biotransformation studies in Caco-2 cells and ICP-MS detection. Biological trace element research 2012;145:248-56. [Google Scholar]
Weekley CM, Harris HH. Which form is that? The importance of selenium speciation and metabolism in the prevention and treatment of disease. Chem Soc Rev 2013;42:8870-94. [Google Scholar]
Kobayashi Y, Ogra Y, Ishiwata K, Takayama H, Aimi N, Suzuki KT. Selenosugars are key and urinary metabolites for selenium excretion within the required to low-toxic range. Proc Natl Acad Sci U S A 2002;99:15932-6. [Google Scholar]
Untoro J, Ruz M, Gross R. Low environmental selenium availability as an additional determinant for goiter in East Java, Indonesia. Biological trace element research 1999;70:127-36. [Google Scholar]
Bachtiar H. Faktor Determinan Kejadian Gondok di Daerah Pantai Jawa Timur. Jurnal Kesehatan Masyarakat Andalas 2009;3:62-7. [Google Scholar]
Wasowicz W, Gromadzinska J, Rydzynski K, Tomczak J. Selenium status of low-selenium area residents: Polish experience. Toxicology Letters 2003;137:95-101. [Google Scholar]
Park K, Rimm E, Siscovick D, Spiegelman D, Morris JS, Mozaffarian D. Demographic and lifestyle factors and selenium levels in men and women in the US. Nutrition research and practice 2011;5:357-64. [Google Scholar]
Waegeneers N, Thiry C, Temmerman, L. De , Ruttens A. Predicted dietary intake of selenium by the general adult population in Belgium. Food Additives & Contaminants: Part A 2013;30:278-85. [Google Scholar]
Widiastuti IKSJY. Aspek Molekuler Hubungan Asupan Zinc dan Selenium dengan Hemoglobin Glikosilasi pada Pasien Diabetes Mellitus Tipe 2. Journal of Biota 2016;1.
Finley JW. Bioavailability of selenium from foods. Nutrition reviews 2006;64:146-51. [Google Scholar]
Finley JW, Grusak MA, Keck AS, Gregoire BR. Bioavailability of selenium from meat and broccoli as determined by retention and distribution of 75Se. Biological trace element research 2004;99:191. [Google Scholar]
Ilkhani F, Hosseini B, Saedisomeolia A. Niacin and oxidative stress: a mini review. Journal of Nutritional Medicine and Diet Care 2016;2:2-14. [Google Scholar]
Chauhan S, Liu F, Leury B, Cottrell J, Celi P, Dunshea F. Functionality and genomics of selenium and vitamin E supplementation in ruminants. Animal Production Science 2016;56:1285-98. [Google Scholar]
Hill KE, Wu S, Motley AK, Stevenson TD, Winfrey VP, Capecchi MR, et al. Production of selenoprotein P (Sepp1) by hepatocytes is central to selenium homeostasis. Journal of biological chemistry 2012 Nov;287(48):40414-24. [Google Scholar]
Renko K, Werner M, Renner-Müller I, Cooper TG, Yeung CH, Hollenbach B, et al. Hepatic selenoprotein P (SePP) expression restores selenium transport and prevents infertility and motor-incoordination in Sepp-knockout mice. Biochemical Journal 2008;409:741-9. [Google Scholar]
Hill KE, Zhou J, McMahan WJ, Motley AK, Burk RF. Neurological dysfunction occurs in mice with targeted deletion of the selenoprotein P gene. The Journal of nutrition 2004;134:157-61. [Google Scholar]
Calissendorff J, Mikulski E, Larsen EH, Möller M. A prospective investigation of Graves' disease and selenium: thyroid hormones, auto-antibodies and self-rated symptoms. European thyroid journal 2015;4:93-8. [Google Scholar]
Janegova A, Janega P, Rychly B, Kuracinova K, Babal P. The role of Epstein-Barr virus infection in the development of autoimmune thyroid diseases. Endokrynologia Polska 2015;66:132-6.
Aaseth J, Frey H, Glattre E, Norheim G, Ringstad J, Thomassen Y. Selenium concentrations in the human thyroid gland. Biological trace element research 1990;24:147-52. [Google Scholar]
Beckett GJ, Arthur JR. Selenium and endocrine systems. Journal of endocrinology 2005;184:455-65.
Flohé L, Aumann KD, Steinert P. Role of selenium in the enzymatic reduction of hydroperoxides. Phosphorus, Sulfur, and Silicon and the Related Elements 1998;136:25-42. [Google Scholar]
Guerra LN, MdCR dM, Miler EA, Moiguer S, Karner M, Burdman JA. Antioxidants and methimazole in the treatment of Graves' disease: effect on urinary malondialdehyde levels. Clinica chimica acta 2005;352:115-20. [Google Scholar]
Tan L, Sang ZN, Shen J, Wu YT, Yao ZX, Zhang JX, et al. Selenium supplementation alleviates autoimmune thyroiditis by regulating expression of TH1/TH2 cytokines. Biomed Environ Sci 2013;26:920-5. [Google Scholar]
Contempré B, Escobar, G.M. De , Denef JF, Dumont JE, Many MC. Thiocyanate induces cell necrosis and fibrosis in selenium-and iodine-deficient rat thyroids: a potential experimental model for myxedematous endemic cretinism in central Africa. Endocrinology 2004;145:994-1002. [Google Scholar]
Contempre B, Moine, O. Le , Dumont JE, Denef JF, Many MC. Selenium deficiency and thyroid fibrosis. A key role for macrophages and transforming growth factor β (TGF-β. Molecular and Cellular Endocrinology 1996;124:7-15. [Google Scholar]
Vanderpas JB, Contempre B, Duale NL, Deckx H, Bebe N, Longombé AO, et al. Selenium deficiency mitigates hypothyroxinemia in iodine-deficient subjects. The American journal of clinical nutrition 1993;57:271. [Google Scholar]
Winther KH, Bonnema SJ, Cold F, Debrabant B, Nybo M, Cold S, et al. Does selenium supplementation affect thyroid function? Results from a randomized, controlled, double-blinded trial in a Danish population. European journal of endocrinology 2015;172:657-67. [Google Scholar]
Rasmussen LB, Schomburg L, Kohrle J, Pedersen IB, Hollenbach B, Hog A, et al. Selenium status, thyroid volume, and multiple nodule formation in an area with mild iodine deficiency. Eur J Endocrinol 2011;164:585-90. [Google Scholar]
Marinò M, Marcocci C, Vitti P, Chiovato L, Bartalena L. Selenium in the Treatment of Thyroid Diseases. European thyroid journal 2017;6:113-4. [Google Scholar]
Leo M, Bartalena L, Dottore GR, Piantanida E, Premoli P, Ionni I, et al. Effects of selenium on short-term control of hyperthyroidism due to Graves’ disease treated with methimazole: results of a randomized clinical trial. Journal of endocrinological investigation 2017;40:281-7. [Google Scholar]
Hoffmann FW, Hashimoto AC, Shafer LA, Dow S, Berry MJ, Hoffmann PR. Dietary Selenium Modulates Activation and Differentiation of CD4+ T Cells in Mice through a Mechanism Involving Cellular Free Thiols–3. The Journal of nutrition 2010;140:1155-61. [Google Scholar]
Farias, C. De , Cardoso B, Oliveira, G. de , de Mello Guazzelli I, , Catarino R, Chammas M, et al. A randomized-controlled, double-blind study of the impact of selenium supplementation on thyroid autoimmunity and inflammation with focus on the GPx1 genotypes. Journal of endocrinological investigation 2015;38:1065-74. [Google Scholar]
Perros P, Žarković M, Azzolini C, Ayvaz G, Baldeschi L, Bartalena L, et al. PREGO (presentation of Graves’ orbitopathy) study: changes in referral patterns to European Group On Graves’ Orbitopathy (EUGOGO) centres over the period from 2000 to 2012. British Journal of Ophthalmology 2015;99:1531-5. [Google Scholar]
Marcocci C, Kahaly GJ, Krassas GE, Bartalena L, Prummel M, Stahl M, et al. Selenium and the course of mild Graves' orbitopathy. New England Journal of Medicine 2011;364:1920-31. [Google Scholar]
Esposito D, Rotondi M, Accardo G, Vallone G, Conzo G, Docimo G, et al. Influence of short-term selenium supplementation on the natural course of Hashimoto’s thyroiditis: clinical results of a blinded placebo-controlled randomized prospective trial. Journal of endocrinological investigation 2017;40:83-9. [Google Scholar]
Pilli T, Cantara S, Schomburg L, Cenci V, Cardinale S, Heid EC, et al. IFNγ-inducible chemokines decrease upon selenomethionine supplementation in women with euthyroid autoimmune thyroiditis: comparison between two doses of selenomethionine (80 or 160 μg) versus placebo. European thyroid journal 2015;4:226-33. [Google Scholar]
Mazokopakis EE, Papadakis JA, Papadomanolaki MG, Batistakis AG, Giannakopoulos TG, Protopapadakis EE, et al. Effects of 12 months treatment with L-selenomethionine on serum anti-TPO Levels in Patients with Hashimoto's thyroiditis. Thyroid 2007;17:609-12. [Google Scholar]
Toulis KA, Anastasilakis AD, Tzellos TG, Goulis DG, Kouvelas D. Selenium supplementation in the treatment of Hashimoto's thyroiditis: a systematic review and a meta-analysis. Thyroid 2010;20:1163-73. [Google Scholar]
Zuuren, E.J. van , Albusta AY, Fedorowicz Z, Carter B, Pijl H. Selenium supplementation for Hashimoto's thyroiditis: summary of a Cochrane Systematic Review. European thyroid journal 2014;3:25-31. [Google Scholar]
Winther KH, Wichman JEM, Bonnema SJ, Hegedüs L. Insufficient documentation for clinical efficacy of selenium supplementation in chronic autoimmune thyroiditis, based on a systematic review and meta-analysis: Springer, 2017.
Vrca V, Mayer L, Škreb F, Rahelić D, Marušić S. Antioxidant supplementation and serum lipids in patients with Graves' disease: Effect on LDL-cholesterol. Acta Pharmaceutica 2012;62:115-22. [Google Scholar]
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