The effect of omega 3 fatty acid supplementation on HbA1c serum in geriatric patients with type 2 diabetes mellitus: an evidence-based case report

Marvin Marino, Lily Indriani Octovia


Background: The prevalence of diabetes mellitus as a non-communicable diseases increase annually. The global prevalence doubled from 4.7% to 8.5% in 1980 until 2016. Insulin resistance is the primary cause of type 2 diabetes mellitus. Polyunsaturated fatty acid has a contribution to membrane fluidity as well as the cell signaling system. The result of studies about the correlation between Omega-3 supplementation and blood glucose control in patients with type 2 diabetes is still inconsistent. Meanwhile, we considered to give a 86 year old woman with an uncontrolled type 2 diabetes omega-3 fatty acid supplementation for controlling her blood glucose. Thus, we performed an evidence-based case report to respond this problem.

Objectives: To observe the effect of omega-3 supplementation on glycated hemoglobin (HbA1c) serum of type 2 diabetes mellitus patients. 

Methods: Electronic literature searching was performed with Cochrane®, Scopus®, and Pubmed®. Inclusion and exclusion criteria were applied by MeSH term and title/abstract with clinical trial as the study design. Critical appraisal was performed for eligible article.

Results: There were three articles relevant with the eligibility criteria and clinical question. One study  found that omega-3 supplementation did not give a significant effect on HbA1c. The other two studies. found that there were improvement on HbA1c and lipid profile in patients that consumed omega 3.

Conclusions: Omega-3 supplementation has inconsistent results for the improvement of HbA1c. The omega-3 lowering effect of HbA1c depends on the source, dosage, and duration of supplementation.


Type 2 diabetes mellitus; omega-3 fatty acid; HbA1c

Full Text:



Wang F, Wang Y, Zhu Y, et al. Treatment for 6 months with fish oil-derived n-3 polyunsaturated fatty acids has neutral effects on glycemic control but improves dyslipidemia in type 2 diabetic patients with abdominal obesity: a randomized, double-blind, placebo-controlled trial. Eur J Nutr 2017;56:2415-22.

WHO. Global Reports on Diabetes. World Health Organization 2016.

Soelistijo SA, Novida H, Rudijanto A, et al. Konsensus Pengelolaan dan Penatalaksanaan Diabetes Melitus Tipe 2 Di Indonesia 2015. PB Perkeni; 2015.

Hasil Utama Riskesdas 2018. In: Kesehatan K, ed.: Kementrian Kesehatan Republik Indonesia; 2018.

Von Frankenberg AD, Marina A, Song X, Callahan HS, Kratz M, Utzschneider KM. A high-fat, high-saturated fat diet decreases insulin sensitivity without changing intra-abdominal fat in weight-stable overweight and obese adults. Eur J Nutr 2017;56:431-43.

Imamura F, Micha R, Wu JH, et al. Effects of Saturated Fat, Polyunsaturated Fat, Monounsaturated Fat, and Carbohydrate on Glucose-Insulin Homeostasis: A Systematic Review and Meta-analysis of Randomised Controlled Feeding Trials. PLoS Med 2016;13:e1002087.

Lepretti M, Martucciello S, Aceves MAB, Putti R, Lionetti L. Omega-3 Fatty Acids and Insulin Resistance: Focus on the Regulation of Mitochondria and Endoplasmic Reticulum Stress. Nutrients 2018;10.

Critical Appraisal for Therapy Articles. Center for Evidence-Based Medicine University of Oxford.

Howick J, Chalmers I, Glasziou P, et al. Oxford Centre for Evidence-Based Medicine 2011 Levels of Evidence. Oxford Centre for Evidence-Based Medicine 2011.

Soleimani Z, Hashemdokht F, Bahmani F, Taghizadeh M, Memarzadeh MR, Asemi Z. Clinical and metabolic response to flaxseed oil omega-3 fatty acids supplementation in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial. J Diabetes Complications 2017;31:1394-400.

Zheng JS, Lin M, Fang L, et al. Effects of n-3 fatty acid supplements on glycemic traits in Chinese type 2 diabetic patients: A double-blind randomized controlled trial. Mol Nutr Food Res 2016;60:2176-84.

Simonetto M, Infante M, Sacco RL, Rundek T, Della-Morte D. A Novel Anti-Inflammatory Role of Omega-3 PUFAs in Prevention and Treatment of Atherosclerosis and Vascular Cognitive Impairment and Dementia. Nutrients 2019;11.



  • There are currently no refbacks.

Copyright (c) 2020 Marvin Marino

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

View My Stats