Metabolic effects of monounsaturated fatty acid−enriched diets on glycaemic control in patient with type 2 diabetes: an evidence-based case report

  • Krisadelfa Sutanto Faculty of Medicine, University of Indonesia, Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia
  • Diana Sunardi Faculty of Medicine, University of Indonesia, Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia
  • arieska felicia Faculty of Medicine, University of Indonesia, Dr Cipto Mangunkusumo General Hospital
Keywords: T2D, MUFA, glucose fasting, HbA1c

Abstract

Introduction: Diabetes mellitus type 2 (T2D) is the most common type of diabetes. There is an ongoing debate as to whether nutrient quality or quantity is mainly responsible for the effects on hyperglycaemic control of patients with T2D. Monounsaturated fatty acid (MUFA) has a metabolic effect in reducing the risk factor for metabolic syndrome to prevent and control hyperglycaemia in patients with T2D and is recommended by professional organizations. Methods: Literature searching was conducted by advanced searching in Pubmed, Cochrane Library, Scopus, and ProQuest database using MeSH Terms combined with Title/Abstract. After removing duplicates, the literature were screened based on the eligibility criteria. Critical appraisal and level of evidence of the selected literature were determined based on Oxford Centre for Evidence-Based Medicine. Results: Two selected literature were relevant to answer our clinical question, both literature are systematic review/meta-analysis studies. The first literature is a study by Fumiaki et al. (2016), while the second is by Frank Qian et al. (2016). All literature provided evidence that a diet high in MUFA could improve glucose-insulin homeostasis among patients with T2D. These effects were marked by lower fasting blood glucose and haemoglobin A1c (HbA1c), and insulin level in the enriched MUFA diet group compared to PUFA. Conclusion: Nutrient quality is mainly responsible for the effects on glycaemic control profile in patients with T2D, with a high MUFA diet consistent with favourable effects to improve fasting glucose and HbA1c.

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Author Biographies

Krisadelfa Sutanto, Faculty of Medicine, University of Indonesia, Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia
Department of Nutrition
Diana Sunardi, Faculty of Medicine, University of Indonesia, Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia
Department of Nutrition
arieska felicia, Faculty of Medicine, University of Indonesia, Dr Cipto Mangunkusumo General Hospital
Department of Nutrition  

References

Neuenschwander M, Barbaresko J, Pischke CR, Iser N, Beckhaus J, Schwingshackl L, et al. Intake of dietary fats and fatty acids and the incidence of type 2 diabetes: A systematic review and dose-response meta-analysis of prospective observational studies. Vol. 17, PLoS Medicine. 2020.

Zhuang P, Zhang Y, Mao L, Wang L, Wu F, Cheng L, et al. The association between consumption of monounsaturated fats from animal- v. plant-based foods and the risk of type 2 diabetes: A prospective nationwide cohort study. Br J Nutr. 2020;124(1):102–11.

Pedoman Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 Dewasa di Indonesia 2015. (2015). PB PERKENI.

Wanders AJ, Alssema M, De Koning EJP, Le Cessie S, De Vries JH, Zock PL, et al. Fatty acid intake and its dietary sources in relation with markers of type 2 diabetes risk: The NEO study. Eur J Clin Nutr. 2017;71(2):245–51.

Sarabhai T, Kahl S, Szendroedi J, Markgraf DF, Zaharia OP, Barosa C, et al. Monounsaturated fat rapidly induces hepatic gluconeogenesis and whole-body insulin resistance. JCI Insight. 2020;5(10).

Guasch-Ferré M, Zong G, Willett WC, Zock PL, Wanders AJ, Hu FB, et al. Associations of monounsaturated fatty acids from plant and animal sources with total and cause-specific mortality in two us prospective cohort studies. Circ Res. 2019;124(8):1266–75.

Schwingshackl L, Strasser B, Hoffmann G. Effects of monounsaturated fatty acids on glycaemic control in patients with abnormal glucose metabolism: A systematic review and meta-analysis. Ann Nutr Metab. 2011;58(4):290–6.

Qian F, Korat AA, Malik V, Hu FB. Metabolic effects of monounsaturated fatty acid-enriched diets compared with carbohydrate or polyunsaturated fatty acid-enriched diets in patients with type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials. Diabetes Care. 2016;39(8):1448–57.

Imamura F, Micha R, Wu JHY, Otto MCDO, Otite FO, Abioye AI, et al. Effects of Saturated Fat , Polyunsaturated Fat , Monounsaturated Fat , and Carbohydrate on Glucose-Insulin Homeostasis : A Systematic Review and Meta-analysis of Randomised Controlled Feeding Trials. 2016;1–18. Available from: http://dx.doi.org/10.1371/journal.pmed.1002087

Gillingham LG, Harris-Janz S, Jones PJH. Dietary monounsaturated fatty acids are protective against metabolic syndrome and cardiovascular disease risk factors. Lipids. 2011;46(3):209–28.

Barros CR De, Cezaretto A, Ladeia M, Curti R, Pires MM, Folchetti LD, et al. Realistic changes in monounsaturated fatty acids and soluble fibers are able to improve glucose metabolism. Diabetology & Metabolic Syndrome. 2014;1–8.

Submitted

2023-01-08
Accepted
2023-02-07
Published
2023-02-28