Effect of oral vitamin E supplementation on lipid profile in diabetes mellitus: evidence based case report

  • Indah Sri Wulandari Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia
  • Krisadelfa Sutanto Faculty of Medicine University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia
Keywords: vitamin E, supplement, diabetes mellitus, lipid profile


Introduction: Diabetes mellitus, a prominent non-communicable disease, presents as a chronic condition associated with various complications, including heart disease, nerve damage, chronic kidney disease, and dyslipidemia. A pivotal abnormality in diabetic dyslipidemia is insulin resistance, which stimulates the production of Hepatic VLDL1 (very-low-density lipoprotein 1). The resulting overproduction of VLDL1 is metabolically linked to an abundance of small, dense LDL (low-density lipoprotein) particles and a reduction in large, cholesterol-rich HDL2 (high-density lipoprotein). Conversely, vitamin E, known for its antioxidant and anti-inflammatory properties, acts as a remover of peroxyl radicals, preventing lipid oxidation and safeguarding polyunsaturated fatty acids (PUFA) within cells and plasma lipoproteins. Method: This study investigates the impact of oral vitamin E supplementation on the lipid profile in diabetic patients. Employing advanced search techniques on databases like PubMed, Cochrane Library, and Google Scholar, we conducted a comprehensive literature search using MeSH terms, advanced search methods, and specific eligibility criteria. The results yielded one systematic review with a meta-analysis and two randomized controlled trials (RCTs) that met the predefined PICO and eligibility criteria. Results:  The systematic review and meta-analysis, along with one RCT, reported no significant reduction in lipid profiles with oral vitamin E supplementation in diabetic patients. In contrast, the other RCT observed an improvement in lipid profiles among diabetic patients receiving oral vitamin E supplementation. Conclusion: Supplementing with oral vitamin E does not enhance the lipid profile of individuals with diabetes mellitus.


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Author Biographies

Indah Sri Wulandari, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia
Department of Nutrition
Krisadelfa Sutanto, Faculty of Medicine University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia
Department of Nutrition


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