Effect of omega-3 supplementation on osteoarthritis: An evidence-based case report
Abstract
Background: Osteoarthritis is marked by mild inflammation, causing cartilage damage that leads to bone remodelling and potentially reduces the quality of life. Omega-3 has anti-inflammatory properties, which can help mitigate cartilage damage. Objective: This research aims to determine the role of omega-3 in relieving pain in patients with osteoarthritis. Methods: A literature search was conducted using advanced searching on three large databases: PubMed, Cochrane, and Scopus. The search used Mesh terms according to the criteria. After assessing the relevance and suitability of the literature, two articles were selected and critically evaluated based on Oxford Center for Evidence-Based Medicine. Results: Two systematic review-meta-analyses that meet the PICO and eligibility criteria were found. One of the literature sources does not demonstrate the effect of omega-3 supplementation on joint pain, while the other literature source shows the beneficial effects of omega-3 in reducing joint pain in osteoarthritis. Conclusion: Omega-3 supplementation can alleviate joint pain in individuals with osteoarthritis. Providing omega-3 may be worth considering.Downloads
References
He Y, Li Z, Alexander PG, Ocasio-Nieves BD, Yocum L, Lin H, et al. Pathogenesis of osteoarthritis: risk factors, regulatory pathways in chondrocytes, and experimental models. Biology (Basel). 2020 Jul 29;9(8):194. doi: 10.3390/biology9080194
Kloppenburg M, Berenbaum F. Osteoarthritis year in review 2019: epidemiology and therapy. Osteoarthr Cartil. 2020 Mar;28(3):242–8. doi: 10.1016/j.joca.2020.01.002
Hootman JM, Helmick CG, Barbour KE, Theis KA, Boring MA. Updated projected prevalence of self-reported doctor-diagnosed arthritis and arthritis-attributable activity limitation among US adults, 2015-2040. Arthritis Rheumatol. 2016 Jul;68(7):1582–7. doi: 10.1002/art.39692.
Kementerian Kesehatan Republik Indonesia. Hasil Utama Riskesdas 2018. 2018. Available from: http://www.depkes.go.id/resources/download/info terkini/materi_rakorpop_2018/ Hasil Riskesdas 2018.pdf
Cordingley DM, Cornish SM. Omega-3 fatty acids for the management of osteoarthritis: a narrative review. Nutrients. 2022 Aug 16;14(16):3362. doi: 10.3390/nu14163362
Centers for Disease Control and Prevention. Osteoarthritis. 2020 [cited 2023 Jun 20]. Available from: https://www.cdc.gov/arthritis/basics/osteoarthritis.htm
Kye SY, Park K. Suicidal ideation and suicidal attempts among adults with chronic diseases: a cross-sectional study. Compr Psychiatry. 2017 Feb;73:160–7. doi: 10.1016/ j.comppsych.2016.12.001
Indonesian Rheumatology Association. Rekomendasi IRA untuk diagnosis dan penatalaksanaan Osteoarthritis. Jakarta; 2014.
Sun Y, Zuo Z, Kuang Y. An emerging target in the battle against osteoarthritis: macrophage polarization. Int J Mol Sci. 2020 Nov 12;21(22):8513. doi: 10.3390/ijms21228513
Baker KR, Matthan NR, Lichtenstein AH, Niu J, Guermazi A, Roemer F, et al. Association of plasma n-6 and n-3 polyunsaturated fatty acids with synovitis in the knee: the MOST study. Osteoarthr Cartil. 2012 May;20(5):382–7. doi: 10.1016/j.joca.2012.01.021. Epub 2012 Feb 4.
Saini RK, Keum YS. Omega-3 and omega-6 polyunsaturated fatty acids: dietary sources, metabolism, and significance — a review. Life Sci. 2018 Jun;203:255–67. doi: 10.1016/j.lfs.2018.04.049. Epub 2018 Apr 30.
Senftleber N, Nielsen S, Andersen J, Bliddal H, Tarp S, Lauritzen L, et al. Marine oil supplements for arthritis pain: a systematic review and meta-analysis of randomized trials. Nutrients. 2017 Jan 6;9(1):42. doi: 10.3390/nu9010042.
Deng W, Yi Z, Yin E, Lu R, You H, Yuan X. Effect of omega-3 polyunsaturated fatty acids supplementation for patients with osteoarthritis: a meta-analysis. J Orthop Surg Res. 2023 May 24;18(1):381. doi: 10.1186/s13018-023-03855-w.
Benabdoune H, Rondon EP, Shi Q, Fernandes J, Ranger P, Fahmi H, et al. The role of resolvin D1 in the regulation of inflammatory and catabolic mediators in osteoarthritis. Inflamm Res. 2016 Aug 7;65(8):635–45. doi: 10.1007/s00011-016-0946-x.
Chen Y, Zhang D, Ho KW, Lin S, Suen WCW, Zhang H, et al. GPR120 is an important inflammatory regulator in the development of osteoarthritis. Arthritis Res Ther. 2018 Dec 3;20(1):163. doi.org/10.1186/s13075-018-1660-6.
Xie Y, Zhou W, Zhong Z, Yu H, Zhang P, Shen H. Docosahexaenoic acid inhibits bone remodeling and vessel formation in the osteochondral unit in a rat model. Biomed Pharmacother. 2019 Jun;114:108811. doi: 10.1016/j.biopha.2019.108811.
Gropper S, Smith J, Carr T. Advanced Nutrition and Human Metabolism. Boston: Cengage Learning Inc; 2020.
Morgovan C. Nutrivigilance: a new activity in the field of dietary supplements. Farmacia. 2019 May 19;67(3):537–44. doi.org/10.31925/farmacia.2019.3.24.
Submitted
Copyright (c) 2024 Jessica Ferdi, Diana Sunardi
This work is licensed under a Creative Commons Attribution 4.0 International License.
World Nutrition Journal is an open acces journal and under the licence of
