Association of Serum Adiponectin Levels with Metabolic Syndrome Risk Factors in Malay Adults
Abstract
Introduction: This study aimed to investigate the relationship between serum adiponectin and metabolic syndrome in adults living in rural Malaysia.Methods: A total of 299 Malay adults (men=124; women = 175) with a mean age 48.8 (11.7) years were recruited. Measurements for waist circumference and blood pressure were taken before drawing an overnight fasting blood samples. Biochemical tests for triglycerides, HDL cholesterol, glucose and serum adiponectin concentration were measured.Results: Our results show that the adiponectin level in the subjects with metabolic syndrome was significantly lower than those without metabolic syndrome (p < 0.05). Among the metabolic syndrome risk factors, adiponectin level was significantly associated with hypertriglyceridemia and reduced HDL cholesterol (p < 0.001).Conclusion: The outcome from this study which highlights the association of hypoadiponectinemia with risk factors of metabolic syndrome in Malay adults, suggests that the reduced level of adiponectin may play a pivotal role in the development of metabolic syndrome in this ethnic group.Downloads
References
Grundy SM. Metabolic syndrome pandemic. Arterioscler Thromb Vasc Biol 2008;28(4):629-36. [Google Scholar]
Alberti KG, Zimmet P, Shaw J. Metabolic syndrome-a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet Med 2006;23(5):469-80. [Google Scholar]
Lee J, Heng D, Ma S, Chew SK, Hughes K, Tai ES. The metabolic syndrome and mortality: the Singapore Cardiovascular Cohort Study. Clin Endocrinol 2008;69(2):225-30. [Google Scholar]
Aekplakorn W, Chongsuvivatwong V, Tatsanavivat P, Suriyawongpaisal P. Prevalence of metabolic syndrome defined by the International Diabetes Federation and National Cholesterol Education Program criteria among Thai adults. Asia Pac J Public Health 2011;23(5):792-800. [Google Scholar]
Soewondo P, Purnamasari D, Oemardi M, Waspadji S, Soegondo S. Prevalence of metabolic syndrome using NCEP/ATP III criteria in Jakarta, Indonesia: the Jakarta primary non-communicable disease risk factors surveillance 2006. Acta Med Indones 2010;42(4):199-203. [Google Scholar]
Kamso S. Prevalence of metabolic syndrome in older Indonesians. Asia Pac J Public Health 2008;20 Suppl:244-50. [Google Scholar]
Sartika CR, Lukito W, Wijaya A. Adiponectin, total anti-oxidant status, and high sensitivity C-reactive protein in Indonesian men with metabolic syndrome. Medical Journal of Indonesia 2009;18(4):262-8. [Google Scholar]
Zainuddin LR, Isa N, Muda WM, Mohamed HJ. The prevalence of metabolic syndrome according to various definitions and hypertriglyceridemic-waist in malaysian adults. Int J Prev Med 2011;2(4):229-37. [Google Scholar]
Rampal S, Mahadeva S, Guallar E, Bulgiba A, Mohamed R, Rahmat R, et al. Ethnic differences in the prevalence of metabolic syndrome: results from a multi-ethnic population-based survey in Malaysia. PLoS One 2012;7(9):e46365.
Chu AH, Moy FM. Association between physical activity and metabolic syndrome among Malay adults in a developing country, Malaysia. J Sci Med Sport 2014;17(2):195-200. [Google Scholar]
Narayanan P, Meng OL, Mahanim O. Do the prevalence and components of metabolic syndrome differ among different ethnic groups? A cross-sectional study among obese Malaysian adolescents. Metab Syndr Relat Disord 2011;9(5):389-95. [Google Scholar]
Ryo M, Nakamura T, Kihara S, Kumada M, Shibazaki S, Takahashi M, et al. Adiponectin as a biomarker of the metabolic syndrome. Circ J 2004;68(11):975-81. [Google Scholar]
Matsuzawa Y. Establishment of a concept of visceral fat syndrome and discovery of adiponectin. Proc Jpn Acad Ser B Phys Biol Sci 2010;86(2):131-41. [Google Scholar]
Renaldi O, Pramono B, Sinorita H, Purnomo LB, Asdie RH, Asdie AH. Hypoadiponectinemia: a risk factor for metabolic syndrome. Acta Med Indones 2009;41(1):20-4. [Google Scholar]
Wong GW, Wang J, Hug C, Tsao TS, Lodish HF. A family of Acrp30/adiponectin structural and functional paralogs. Proc Natl Acad Sci U S A 2004;101(28):10302-7. [Google Scholar]
Comuzzie AG, Funahashi T, Sonnenberg G, Martin LJ, Jacob HJ, Black AE, et al. The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome. J Clin Endocrinol Metab 2001;86(9):4321-5. [Google Scholar]
Leech NL, Barret KC, Morgan GA. Chapter 8: Factorial ANOVA and ANCOVA. In: SPSS for Intermediate Statistics: Use and Interpretation. 5th edition. New Jersey: Lawrence Erlbaum Associates; 2005. [Google Scholar]
Koh SB, Park JK, Yoon JH, Chang SJ, Oh SS, Kim JY, et al. Preliminary report: a serious link between adiponectin levels and metabolic syndrome in a Korean nondiabetic population. Metabolism 2010;59(3):333-7. [Google Scholar]
Onat A, Hergenc G, Can G, Kucukdurmaz Z. Serum adiponectin confers little protection against diabetes and hypertension in Turkish men. Obesity (Silver Spring 2009;17(3):564-70. [Google Scholar]
Kazumi T, Kawaguchi A, Hirano T, Yoshino G. Serum adiponectin is associated with high-density lipoprotein cholesterol, triglycerides, and low-density lipoprotein particle size in young healthy men. Metabolism 2004;53(5):589-93. [Google Scholar]
King GA, Deemer SE, Thompson DL. Adiponectin is associated with risk of the metabolic syndrome and insulin resistance in women. Acta Diabetol 2012;49 Suppl 1. [Google Scholar]
Huang MC, Wang TN, Lee KT, Wu YJ, Tu HP, Liu CS, et al. Adiponectin gene SNP276 variants and central obesity confer risks for hyperglycemia in indigenous Taiwanese. Kaohsiung J Med Sci 2010;26(5):227-36. [Google Scholar]
Specchia C, Scott K, Fortina P, Devoto M, Falkner B. Association of a polymorphic variant of the adiponectin gene with insulin resistance in african americans. Clin Transl Sci 2008;1(3):194-9. [Google Scholar]
Gavrila A, Chan JL, Yiannakouris N, Kontogianni M, Miller LC, Orlova C, et al. Serum adiponectin levels are inversely associated with overall and central fat distribution but are not directly regulated by acute fasting or leptin administration in humans: cross-sectional and interventional studies. J Clin Endocrinol Metab 2003;88(10):4823-31. [Google Scholar]
Yamamoto Y, Hirose H, Saito I, Tomita M, Taniyama M, Matsubara K, et al. Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein-cholesterol, independent of body mass index, in the Japanese population. Clin Sci (Lond 2002;103(2):137-42. [Google Scholar]
Laughlin GA, Barrett-Connor E, May S, Langenberg C. Association of adiponectin with coronary heart disease and mortality: the Rancho Bernardo study. Am J Epidemiol 2007;165(2):164-74. [Google Scholar]
Rathmann W, Haastert B, Herder C, Hauner H, Koenig W, Meisinger C, et al. Differential association of adiponectin with cardiovascular risk markers in men and women? The KORA survey 2000. Int J Obes (Lond 2007;31(5):770-6. [Google Scholar]
Eynatten, M. von , Schneider JG. The role of adiponectin in atherosclerosis: do lipids tip the scales. Future Cardiol 2005;1(6):775-84. [Google Scholar]
Staiger H, Tschritter O, Machann J, Thamer C, Fritsche A, Maerker E, et al. Relationship of serum adiponectin and leptin concentrations with body fat distribution in humans. Obes Res 2003;11(3):368-72. [Google Scholar]
Seino Y, Hirose H, Saito I, Itoh H. High-molecular-weight adiponectin is a predictor of progression to metabolic syndrome: a population-based 6-year follow-up study in Japanese men. Metabolism 2009;58(3):355-60. [Google Scholar]
Lara-Castro C, Luo N, Wallace P, Klein RL, Garvey WT. Adiponectin multimeric complexes and the metabolic syndrome trait cluster. Diabetes 2006;55(1):249-59. [Google Scholar]
Hanley AJ, Bowden D, Wagenknecht LE, Balasubramanyam A, Langfeld C, Saad MF, et al. Associations of adiponectin with body fat distribution and insulin sensitivity in nondiabetic Hispanics and African-Americans. J Clin Endocrinol Metab 2007;92(7):2665-71. [Google Scholar]
Furuhashi M, Ura N, Higashiura K, Murakami H, Tanaka M, Moniwa N, et al. Blockade of the renin-angiotensin system increases adiponectin concentrations in patients with essential hypertension. Hypertension 2003;42(1):76-81. [Google Scholar]
Francischetti EA, Celoria BM, Duarte SF, Silva, E.G. da , Santos IJ, Cabello PH, et al. Hypoadiponectinemia is associated with blood pressure increase in obese insulin-resistant individuals. Metabolism 2007;56(11):1464-9. [Google Scholar]
Hotta K, Funahashi T, Arita Y, Takahashi M, Matsuda M, Okamoto Y, et al. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 2000;20(6):1595-9. [Google Scholar]
Tschritter O, Fritsche A, Thamer C, Haap M, Shirkavand F, Rahe S, et al. Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism. Diabetes 2003;52(2):239-43. [Google Scholar]
Daimon M, Oizumi T, Saitoh T, Kameda W, Hirata A, Yamaguchi H, et al. Decreased serum levels of adiponectin are a risk factor for the progression to type 2 diabetes in the Japanese Population: the Funagata study. Diabetes Care 2003;26(7):2015-20. [Google Scholar]
Spranger J, Kroke A, Mohlig M, Bergmann MM, Ristow M, Boeing H, et al. Adiponectin and protection against type 2 diabetes mellitus. Lancet 2003;361(9353):226-8. [Google Scholar]
Vendramini MF, Pereira AC, Ferreira SR, Kasamatsu TS, Moises RS. Association of genetic variants in the adiponectin encoding gene (ADIPOQ) with type 2 diabetes in Japanese Brazilians. J Diabetes Complications 2010;24(2):115-20. [Google Scholar]
Zhu W, Cheng KK, Vanhoutte PM, Lam KS, Xu A. Vascular effects of adiponectin: molecular mechanisms and potential therapeutic intervention. Clin Sci (Lond 2008;114(5):361-74. [Google Scholar]
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