The Role of Iron for Supporting Children’s Growth and Development

Main Article Content

Bernie Endyarni Medise

Abstract

According to the World Health Organization (WHO), Iron Deficiency (ID) affects around 2 billion people worldwide. Early childhood ID has been associated with permanent cognitive deficits associated with CNS structural, metabolic impairment, growth retardation, impaired immune response, psychological abnormalities, and behavioral delays. This literature review will focus on the important role of iron in child growth and development.
Iron is necessary for various cellular processes in the growing brain especially when it comes to memory and learning. Children with early ID show cognitive deficits that persist; however, prompt iron treatment soothes the problem. A chronic ID group reported substantially lower scores of vocabularies, ambient sound perception, and motor measurements in a recent study relative to infants with normal nutritional iron status at 6 months and 14-18 months. Children's iron requirement differentiates based on individual age. The daily iron requirement for one- to three-year-old children is 7 mg. Some risk factors of infants and toddlers in developing ID are insufficient food intake, poor bioavailability, reduced absorption, increase demand, increase losses, cow’s milk enteropathy hookworm infection, and maternal gestation.
Iron plays an important role in promoting children's growth and development. Physical health and nutrition are important in the first two years of life. Children who are unable to achieve iron adequacy will possibly show permanent cognitive deficit and impaired motor growth. Thus, iron supplementation may only be successful in early prescription after diagnosing iron deficiency.

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Author Biography

Bernie Endyarni Medise, Faculty of Medicine, Universitas Indonesia

Department of Child Health

References

Yousafzai AK, Rasheed MA, Rizvi A, Armstrong R, Bhutta ZA. 2014.Effect of integrated responsive stimulation and nutrition interventions in the Lady Health Worker programme in Pakistan on child development, growth, and health outcomes: a cluster-randomised factorial effectiveness trial. The Lancet. 384(9950):1282-93.

Cusick SE, Georgieff MK. 2016.The Role of Nutrition in Brain Development: The Golden Opportunity of the First 1000 Days old. The Journal of Pediatrics. 175:16-21.

Aboud FE, Yousafzai AK. 2015.Global Health and Development in Early Childhood. Annual Review of Psychology. 66(1):433-57.

Fretham SJ, Carlson ES, Georgieff MK. 2011.The role of iron in learning and memory. Advances in Nutrition. 2(2):112-21.

Pasricha S-R, Hayes E, Kalumba K, Biggs B-A. 2013.Effect of daily iron supplementation on health in children aged 4–23 months: a systematic review and meta-analysis of randomised controlled trials. The Lancet Global Health. 1(2):e77-e86.

Thomas DG, Grant SL, Aubuchon-Endsley NL. 2009.The role of iron in neurocognitive development. Developmental neuropsychology. 34(2):196-222.

Mohammed SH, Esmaillzadeh A. 2017.The relationships among iron supplement use, Hb concentration and linear growth in young children: Ethiopian Demographic and Health Survey. British Journal of Nutrition. 118(9):730-6.

Izquierdo-Álvarez S, Urrechaga-Igartua E, Llorente-Ballesteros MT, Escanero JF. The Role of Iron and Other Trace Elements on Mental Development and Cognitive Function. Psychiatry and Neuroscience Update: Springer; 2015. p. 157-79.

Dobbing J. Brain, behaviour, and iron in the infant diet: Springer Science & Business Media; 2013.

Jáuregui-Lobera I. 2014.Iron deficiency and cognitive functions. Neuropsychiatric disease and treatment. 10:2087.

McCann S, Perapoch Amadó M, Moore SE. 2020.The Role of Iron in Brain Development: A Systematic Review. Nutrients. 12(7):2001.

Ferreira A, Neves P, Gozzelino R. 2019.Multilevel impacts of Iron in the brain: the cross talk between neurophysiological mechanisms, cognition, and social behavior. Pharmaceuticals. 12(3):126.

Mattei D, Pietrobelli A. 2019.Micronutrients and brain development. Current Nutrition Reports. 8(2):99-107.

Pettit K, Rowley J, Brown N. 2011.Iron deficiency. Paediatrics and Child Health. 21(8):339-43.

Domellöf M, Braegger C, Campoy C, Colomb V, Decsi T, Fewtrell M, et al. 2014.Iron requirements of infants and toddlers. Journal of pediatric gastroenterology and nutrition. 58(1):119-29.

Eussen S, Alles M, Uijterschout L, Brus F, Van Der Horst-graat J. 2015.Iron intake and status of children aged 6-36 months in Europe: a systematic review. Annals of Nutrition and Metabolism. 66(2-3):80-92.

Dreyfuss ML, Green M, Hadihardjono DN, Izwardy D, Huffman SL. 2019.Commercially produced complementary foods in Bandung City, Indonesia, are often reported to be iron fortified but with less than recommended amounts or suboptimal forms of iron. Maternal & Child Nutrition. 15:e12789.

Cappellini MD, Musallam KM, Taher AT. 2020.Iron deficiency anaemia revisited. Journal of internal medicine. 287(2):153-70.

Pasricha S-R, Gheorghe A, Sakr-Ashour F, Arcot A, Neufeld L, Murray-Kolb LE, et al. 2020.Net benefit and cost-effectiveness of universal iron-containing multiple micronutrient powders for young children in 78 countries: a microsimulation study. The Lancet Global Health. 8(8):e1071-e80.

Wang M. 2016.Iron deficiency and other types of anemia in infants and children. Americafamily physician. 93(4):270-8.

Ikatan Dokter Anak Indonesia 2011. Rekomendasi Ikatan Dokter Anak Indonesia : Suplementasi Besi Untuk Anak. Badan Penerbit IDAI