Indonesian health care practitioner’s perception on gut-brain-axis and social-emotional concept

  • Ray Wagiu Basrowi Occupational Medicine Division, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia ; Danone Specialized Nutrition Indonesia
  • Tonny Sundjaya Danone Specialized Nutrition Indonesia
Keywords: gut mirobiota, gut-brain axis, HCP perception, social-emotional


Background The microbiome-gut-brain-axis (GBA) concept has long been appreciated. It is recognized that the microbes resident in the gastrointestinal tract can influence brain physiology and the social-development competencies, and vice versa. Therefore, it is crucial for health care practitioners (HCPs) to understand this concept, especially in children; however, no study has been reported. Methods: This study used qualitative methods to explore HCPs’ perception and awareness about the microbiome-GBA concept. Data were collected through in-depth interviews using online video calls with HCPs, including general practitioners, pediatricians, and midwives. Results: We found that responders are aware of the microbiome-GBA concept, as this issue is often discussed in seminars and other events. They realized that gut health is a significant concern, and it is significantly impacting brain health and leads to social and emotional development (SED). This process starts from the early stages of life. Conclusion: The HCPs in our study have a good perception of the microbiome-GBA concept, e.g., a healthy brain is not possible without a healthy gut. As far as we are concerned, this is the first study to investigate the knowledge of HCPs about bidirectional communication of microbiome-GBA as an essential factor in child management.


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Singhal A. Long-Term Adverse Effects of Early Growth Acceleration or Catch-Up Growth. Annals of nutrition & metabolism. 2017;70(3):236-40.

Koletzko B, Chourdakis M, Grote V, Hellmuth C, Prell C, Rzehak P, et al. Regulation of early human growth: impact on long-term health. Annals of nutrition & metabolism. 2014;65(2-3):101-9.

Investigators M-EN. The MAL-ED study: a multinational and multidisciplinary approach to understanding the relationship between enteric pathogens, malnutrition, gut physiology, physical growth, cognitive development, and immune responses in infants and children up to 2 years of age in resource-poor environments. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2014;59 Suppl 4:S193-206.

Miguel PM, Pereira LO, Silveira PP, Meaney MJ. Early environmental influences on the development of children's brain structure and function. Developmental medicine and child neurology. 2019;61(10):1127-33.

Selma-Royo M, Calatayud Arroyo M, Garcia-Mantrana I, Parra-Llorca A, Escuriet R, Martinez-Costa C, et al. Perinatal environment shapes microbiota colonization and infant growth: impact on host response and intestinal function. Microbiome. 2020;8(1):167.

Cryan JF, O'Riordan KJ, Cowan CSM, Sandhu KV, Bastiaanssen TFS, Boehme M, et al. The Microbiota-Gut-Brain Axis. Physiological reviews. 2019;99(4):1877-2013.

Sherwin E, Bordenstein SR, Quinn JL, Dinan TG, Cryan JF. Microbiota and the social brain. Science. 2019;366(6465).

Cryan JF, Dinan TG. Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nature reviews Neuroscience. 2012;13(10):701-12.

Allen AP, Dinan TG, Clarke G, Cryan JF. A psychology of the human brain-gut-microbiome axis. Social and personality psychology compass. 2017;11(4):e12309.

Brennan PA, Dunlop AL, Smith AK, Kramer M, Mulle J, Corwin EJ. Protocol for the Emory University African American maternal stress and infant gut microbiome cohort study. BMC pediatrics. 2019;19(1):246.

Christian LM, Galley JD, Hade EM, Schoppe-Sullivan S, Kamp Dush C, Bailey MT. Gut microbiome composition is associated with temperament during early childhood. Brain, behavior, and immunity. 2015;45:118-27.

Cuesta-Briand B, Auret K, Johnson P, Playford D. 'A world of difference': a qualitative study of medical students' views on professionalism and the 'good doctor'. BMC medical education. 2014;14:77.

Green J, Britten N. Qualitative research and evidence-based medicine. Bmj. 1998;316(7139):1230-2.

Reed-Knight B LK, Mackner L, Maddux MH, Deacy AD, Stone AL. Brain-Gut Interactions and Maintenance Factors in Pediatric Gastroenterological Disorders; Recommendations for Clinical Care. Clinical Practice in Pediatric Psychology. 2017;5:13.

Bordage G, Carlin B, Mazmanian PE, American College of Chest Physicians H, Science Policy C. Continuing medical education effect on physician knowledge: effectiveness of continuing medical education: American College of Chest Physicians Evidence-Based Educational Guidelines. Chest. 2009;135(3 Suppl):29S-36S.

Bell DS, Harless CE, Higa JK, Bjork EL, Bjork RA, Bazargan M, et al. Knowledge retention after an online tutorial: a randomized educational experiment among resident physicians. Journal of general internal medicine. 2008;23(8):1164-71.

Saptawati Bardosono RH, Dian N. Chandra, Ray W. Basrowi, Yulianti Wibowo. The knowledge retention after continuing health education among midwives in Indonesia. Med J Indones. 2018;27:6.

Liang S, Wu X, Jin F. Gut-Brain Psychology: Rethinking Psychology From the Microbiota-Gut-Brain Axis. Frontiers in integrative neuroscience. 2018;12:33.

Basrowi RW, Krisnamurti D, Wibowo Y, Vandenplas Y (2019) Factors influencing probiotics recommendation among pediatricians in Indonesia. 2019;6:1-4. DOI: 10.15761/IFNM.1000265

Sitorus NL, Dilantika C, Basrowi RW. Perspective of Indonesian Pediatricians On The Role of Prebiotic Supplemented Formula Towards Immunity, Growth and Development In Preterm Infants: A Preliminary Data. Amerta Nutr (2021).supl.34-42. DOI: 10.20473/amnt.V5i1SP.2021.



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