Correlation between Hair Zinc Level and Cognitive Function in Elderly

Main Article Content

Dian Sarah Mutiara
Diana Sunardi
Esthika Dewiasty

Abstract

Background and Objectives : Neurodegenerative disease is the most problem in elderly. Amyloid β (Aβ) accumulation is the major cause of cognitive impairment. Zinc has an important role in antioxidant and Aβ accumulation process. This study aimed to evaluate the correlation between hair zinc level and cognitive function in elderly.Methods : A cross sectional study was conducted involving 58 subjects of elderly in Jakarta. Subjects were recruited by consecutive sampling. Hair zinc level was measured by inductively coupled plasma emission spectrometer (ICPS) and cognitive function assessed by abbreviated mental test (AMT). Data analysis was done by spearman rank correlation test[DN1]  and p-value less than 0.05 was considered statistically significant.Results : The mean of age was 65.4 ± 4.4 years old and 56.9% of subjects were female. The mean of hair zinc level was 123.23 ± 69.71 µg/gram hair and 32.8% subjects had hair zinc deficiency. There was 91.4% subjects had normal cognitive function. The study showed no correlation between hair zinc level and cognitive function in elderly (p=0.871 ; r=-0.022).Conclusion : There was no correlation between hair zinc level and cognitive function in elderly. Further research is expected to be performed with different level of cognitive function.

Downloads

Download data is not yet available.

Article Details

Section
Articles
Author Biographies

Dian Sarah Mutiara, Universitas Indonesia

Department of  Nutrition,Faculty Medicine

Diana Sunardi, Universitas Indonesia

Department of  Nutrition,Faculty Medicine

Esthika Dewiasty, Universitas Indonesia

Department of Internal Medicine, Faculty of Medicine