Dietary Fiber's Effect on High Sensitivity C-reactive Protein Serum in Sedentary Workers

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Livia Kurniati Saputra
Dian Novita Chandra
Ninik Mudjihartini


Low grade inflammation has been recognized of being involved in the pathogenesis of chronic disease pandemic. Individual lifestyle plays a major role in the development of low grade inflammation. Sedentary workers are at risk of low grade inflammation due to the nature of their work. Dietary habit also contributes to inflammatory status in the body. Dietary fiber intake indirectly affects the immune system. It has been hypothesized that fiber has anti-inflammatory effects, both body weight-related and body weight-unrelated This review will focus more on body weight-unrelated anti-inflammatory effect of fiber, especially through fiber’s fermentation metabolites, the short chain fatty acid (SCFA). Its anti-inflammatory effect can be seen by monitoring a biomarker of inflammation in the body, the high sensitivity C-reactive protein (hsCRP). This review’s objective is to cover the mechanisms and role of dietary fiber intake on serum hsCRP level as a marker of low grade inflammation on sedentary workers. 

Article Details

Author Biographies

Livia Kurniati Saputra, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo General Hospital

Department of Nutrition

Dian Novita Chandra, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo General Hospital

Department of Nutrition

Ninik Mudjihartini, Faculty of Medicine, Universitas Indonesia

Department of Biochemistry and Molecular Biology


Fitzpatrick M, Young SP. Europe PMC Funders Group Metabolomics – A novel window into inflammatory disease. Swiss Med Wkly; 143. 2015

Calder PC, Ahluwalia N, Albers R, Bosco N, Bourdet-Sicard R, Haller D, et al. A Consideration of Biomarkers to be Used for Evaluation of Inflammation in Human Nutritional Studies. Br J Nutr. 2013;109.

Henson J, Yates T, Edwardson CL, Khunti K, Talbot D, Gray LJ, et al. Sedentary time and markers of chronic low-grade inflammation in a high risk population. PLoS One. 2013;8(10):4–9.

León-Pedroza JI, González-Tapia LA, del Olmo-Gil E, Castellanos-Rodríguez D, Escobedo G, González-Chávez A. Low-grade systemic inflammation and the development of metabolic diseases: From the molecular evidence to the clinical practice. Cir Cir. 2015;83(6):543–51.

Kamso S, Purwantyastuti P, Lubis DU, Juwita R, Robbi YK, Besral B. Prevalensi dan Determinan Sindrom Metabolik pada Kelompok Eksekutif di Jakarta dan Sekitarnya. Jurnal Kesehatan Masyarakat Nasional. 2011;6(2):85.

Kim JY, Park YH, An EN. The relationship between lifestyles and obesity of office workers in Korea. Int J Control Autom. 2015;8(10):349–60.

Burton WN, Pransky G, Conti DJ, Chen CY, Edington DW. The association of medical conditions and presenteeism. J Occup Environ Med. 2004;46(6 SUPPL.):38–45.

Arima H, Kubo M, Yonemoto K, Doi Y, Ninomiya T, Tanizaki Y, et al. High-sensitivity c-reactive protein and coronary heart disease in a general population of Japanese: The Hisayama study. Arterioscler Thromb Vasc Biol. 2008;28(7):1385–91.

Sproston NR, Ashworth JJ. Role of C-reactive protein at sites of inflammation and infection. Front Immunol. 2018;9(APR):1–11.

Kamath DY, Xavier D, Sigamani A, Pais P. High sensitivity C-reactive protein (hsCRP) & cardiovascular disease: An Indian perspective. Indian J Med Res. 2015;142(September):261–8.

Luan YY, Yao YM. The clinical significance and potential role of C-reactive protein in chronic inflammatory and neurodegenerative diseases. Front Immunol. 2018;9(JUN):1–8.

Myers GL, Rifai N, Tracy RP, Roberts WL, Alexander RW, Biasucci LM, et al. CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: report from the laboratory science discussion group. Circulation. 2004;110(25).

King DE. Dietary fiber, inflammation, and cardiovascular disease. Mol Nutr Food Res. 2005;49(6):594–600.

Dreher ML. Dietary Fiber in Health and Disease. Bendich A, Bales CW, editors. Vol. 6, Journal of Clinical Gastroenterology. Wimberley, TX: Humana Press; 1984. 190 p.

Gibson R, Eriksen R, Chambers E, Gao H, Aresu M, Heard A, et al. Intakes and Food Sources of Dietary Fibre and Their Associations with Measures of Body Composition and Inflammation in UK Adults: Cross-Sectional Analysis of the Airwave Health Monitoring Study. Nutrients. 2019;11.

Edrisi F, Salehi M, Ahmadi A, Fararoei M, Rusta F, Mahmoodianfard S. Effects of supplementation with rice husk powder and rice bran on inflammatory factors in overweight and obese adults following an energy-restricted diet: a randomized controlled trial. Eur J Nutr. 2018;57(2):833–43.

Khorasaniha R, Siassi F, Khajehnasiri F, Qorbani M, Sotoudeh G. Dietary patterns in relation to inflammation in shift workers. BMJ Mil Heal. 2020;166(4):221–6.

Michaud M, Balardy L, Moulis G, Gaudin C, Peyrot C, Vellas B, et al. Proinflammatory cytokines, aging, and age-related diseases. J Am Med Dir Assoc. 2013;14(12):877–82.

Singh T, Newman AB. Inflammatory markers in population studies of aging. Ageing Res Rev. 2011;10(3):319–29.

Ledue TB, Rifai N. Preanalytic and analytic sources of variations in C-reactive protein measurement: Implications for cardiovascular disease risk assessment. Clin Chem. 2003;49(8):1258–71.

MacGregor AJ, Gallimore JR, Spector TD, Pepys MB. Genetic Effects on Baseline Values of C-Reactive Protein and Serum Amyloid A Protein: A Comparison of Monozygotic and Dizygotic Twins. Clin Chem. 2004;50(1):130–4.

Sutliffe JT, Wilson LD, Heer HD De, Foster RL, Jo M. C-reactive protein response to a vegan lifestyle intervention. Complement Ther Med. 2015;23(1):32–7.

Gursoy AY, Caglar GS, Kiseli M, Pabuccu E, Candar T, Demirtas S. CRP at early follicular phase of menstrual cycle can cause misinterpretation for cardiovascular risk assessment. Interv Med Appl Sci. 2015;7(4):143–6.

Oliveira A, Rodríguez-Artalejo F, Lopes C. The association of fruits, vegetables, antioxidant vitamins and fibre intake with high-sensitivity C-reactive protein: Sex and body mass index interactions. Eur J Clin Nutr. 2009;63(11):1345–52.

Milan-Mattos JC, Anibal FF, Perseguini NM, Minatel V, Rehder-Santos P, Castro CA, et al. Effects of natural aging and gender on pro-inflammatory markers. Brazilian J Med Biol Res. 2019;52(9):1–10.

Gameiro CM, Romão F, Castelo-Branco C. Menopause and aging: Changes in the immune system - A review. Maturitas. 2010;67(4):316–20.

Ma Y, Ph D, Hébert JR, Sc D, Li W, Ph D, et al. Association between dietary fiber and markers of systemic inflammation in the Women ’ s Health Initiative Observational Study. Nutrition. 2008:941–9.

Miller DT, Zee RYL, Danik JS, Kozlowski P, Chasman DI, Lazarus R, et al. Association of common CRP gene variants with CRP levels and cardiovascular events. Ann Hum Genet. 2005;69(6):623–38.

Kelley-Hedgepeth A, Lloyd-Jones DM, Colvin A, Matthews KA, Johnston J, Sowers MFR, et al. Ethnic differences in C-reactive protein concentrations. Clin Chem. 2008;54(6):1027–37.

Kawamoto R, Kusunoki T, Abe M, Kohara K, Miki T. An association between body mass index and high-sensitivity C-reactive protein concentrations is influenced by age in community-dwelling persons. Ann Clin Biochem. 2013;50(5):457–64.

Fuentes E, Fuentes F, Vilahur G, Badimon L, Palomo I. Mechanisms of chronic state of inflammation as mediators that link obese adipose tissue and metabolic syndrome. Mediators Inflamm. 2013;2013. [Internet]. Washington DC: American Association for Clinical Chemistry.c2019. [cited on 20 Nov 2019] Available from:

McFarlin BK, Flynn MG, Campbell WW, Craig BA, Robinson JP, Stewart LK, et al. Physical activity status, but not age, influences inflammatory biomarkers and toll-like receptor 4. Journals Gerontol - Ser A Biol Sci Med Sci. 2006;61(4):388–93.

Shen J, Ordovas JM. Impact of genetic and environmental factors on hsCRP Concentrations and response to therapeutic agents. Clin Chem. 2009;55(2):256–64.

Esposito K, Nappo F, Marfella R, Giugliano G, Giugliano F, Ciotola M, et al. Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: Role of oxidative stress. Circulation. 2002;106(16):2067–72.

Konrad D, Wueest S. The gut-adipose-liver axis in the metabolic syndrome. Physiology. 2014;29(5):304–13.

Tsukumo DM, Carvalho BM, Carvalho-Filho MA, Saad MJA. Translational research into gut microbiota: New horizons on obesity treatment: Updated 2014. Arch Endocrinol Metab. 2015;59(2):154–60.

Smidowicz A, Regula J. Effect of Nutritional Status and Dietary Patterns on Human Serum C-Reactive Protein. Adv Nutr. 2015;(9).

Mcloughlin RF, Berthon BS, Jensen ME, Baines KJ, Wood LG. inflammation : a systematic review and meta-analysis. Am J Clin Nutr. 2017;(1).

Li M, van Esch BCAM, Wagenaar GTM, Garssen J, Folkerts G, Henricks PAJ. Pro- and anti-inflammatory effects of short chain fatty acids on immune and endothelial cells. Eur J Pharmacol. 2018;831(April):52–9.

Gao H, Sun Y, Wu Y, Luan B, Wang Y, Qu B, et al. Identification of β-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-κB pathways. Mol Cell. 2004;14(3):303–17.

Chai JT, Digby JE, Choudhury RP. GPR109A and vascular inflammation. Curr Atheroscler Rep. 2013;15(5):325.

Kasubuchi M, Hasegawa S, Hiramatsu T, Ichimura A, Kimura I. Dietary gut microbial metabolites, short-chain fatty acids, and host metabolic regulation. Nutrients. 2015;7(4):2839–49.

Zhou B, Margariti A, Zeng L, Xu Q. Role of histone deacetylases in vascular cell homeostasis and arteriosclerosis. Cardiovasc Res. 2011;90(3):413–20.

Vinolo MAR, Rodrigues HG, Hatanaka E, Sato FT, Sampaio SC, Curi R. Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils. J Nutr Biochem. 2011;22(9):849–55.

Santangelo C, Varì R, Scazzocchio B, Di Benedetto R, Filesi C, Masella R. Polyphenols, intracellular signalling and inflammation. Ann Ist Super Sanita. 2007;43(4):394–405.

Silva FM, De Almeida JC, Feoli AM. Effect of diet on adiponectin levels in blood. Nutr Rev. 2011;69(10):599–612.

Geagea AG, Mallat S, Matar CF, Zerbe R, Filfili E, Francis M, et al. Adiponectin and Inflammation in Health and Disease: An Update. Open Med J. 2018;5(1):20–32.

Ouchi N, Walsh K. Adiponectin anti inflammation. Clin Chim Acta. 2009;380(1–2):24–30.