Nutrients against adipogenesis : aim to cheating age or weight reduction
AbstractObesity is associated with increased risk of conditions such as type 2 diabetes, CHD, hypertension, dyslipidaemia (which are often included in the so-called metabolic syndrome), gall stones, certain types of cancer (breast and colon), osteoarthritis, non-alcoholic steatohepatitis, sleep apnoea, infertility, and many psychological conditions. Moreover, there is a marked reduction in life expectancy of the order of several years.
2. Jeffery E, Church CD, Holtrup B, Colman L, and Rodeheffer MS (2015). Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity. Nat Cell Biol 17, 376–385. [PubMed: 25730471]
3. Wang QA, Tao C, Gupta RK, and Scherer PE (2013). Tracking adipogenesis during white adipose tissue development, expansion and regeneration. Nat Med 19, 1338–1344. [PubMed: 23995282]
4. Haczeyni F, Bell-Anderson KS, and Farrell GC (2018). Causes and mechanisms of adipocyte enlargement and adipose expansion. Obes Rev 19, 406–420. [PubMed: 29243339]
5. Ghaben AL, and Scherer PE (2019). Adipogenesis and metabolic health. Nature reviews Molecular cell biology 20, 242–258. [PubMed: 30610207]
6. Hilgendorf KI, Johnson CT, Mezger A, Rice SL, Norris AM, Demeter J, Greenleaf WJ, Reiter JF, Kopinke D, Jackson PK. Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis. Cell. 2019 Nov 27;179(6):1289-1305.e21. doi: 10.1016/j.cell.2019.11.005. Epub 2019 Nov 21. PMID: 31761534; PMCID: PMC7332222.
7. Wang Y. X. (2010). PPARs: diverse regulators in energy metabolism and metabolic diseases. Cell Res. 20, 124-137.10.1038/cr.2010.13 [PMCID: PMC4084607] [PubMed: 20101262] [CrossRef: 10.1038/cr.2010.13]
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