Immunity as key factors that influence cognitive development on children
Abstract
Immune cells in the central nervous system (CNS) of the fetus are essential for normal neurodevelopment. Innate immunity-related molecules, including cytokines, toll-like receptors and complement family, are known to be expressed in the brain. Microglia, macrophage-like immune cells that reside in the brain and spinal cord, constitute 80% of all immune cells in the brain, making them the most abundant immune cell type. Acquired immunity-related molecules, such as major histocompatibility complex and antibody receptor, are also known to be expressed in the brain. In addition to this, research has demonstrated that they play important functions in the development of the brain. Neurodevelopmental diseases, including schizophrenia, autism spectrum disorders, autism-like obsessive-compulsive behaviours and social impairment, are characterized by a disruption of a wide variety of processes in the developing brain that depend on the normal function of microglia. Enteric infections and malnutrition in the first two years of life are linked to later cognitive impairment. Multiple studies have shown that bacterial and viral illnesses have direct or indirect impacts on cognitive performance in children. The immune system is in constant communication with the central nervous system and participates in the control of behaviour and a range of other essential neurological activities throughout the lifespan.Downloads
References
Vandenbroucke L, Spilt J, Verschueren K, Piccinin C, Baeyens D. The classroom as a developmental context for cognitive development: A meta-analysis on the importance of teacher–student interactions for children’s executive functions. Rev Educ Res. 2018;88(1):125–64.
Mollon J, Knowles EEM, Mathias SR, Gur R, Peralta JM, Weiner DJ, et al. Genetic influence on cognitive development between childhood and adulthood. Mol Psychiatry [Internet]. 2021;26(2):656–65. Available from: http://dx.doi.org/10.1038/s41380-018-0277-0
Prins JR, Eskandar S, Eggen BJL, Scherjon SA. Microglia, the missing link in maternal immune activation and fetal neurodevelopment; and a possible link in preeclampsia and disturbed neurodevelopment? J Reprod Immunol [Internet]. 2018;126(June 2017):18–22. Available from: https://doi.org/10.1016/j.jri.2018.01.004
Ott JA, Castro CD, Deiss TC, Ohta Y, Flajnik MF, Criscitiello MF. Somatic hypermutation of T cell receptor α chain contributes to selection in nurse shark thymus. Elife. 2018;7:1–31.
Pronovost GN, Hsiao EY. Perinatal Interactions between the Microbiome, Immunity, and Neurodevelopment. Immunity [Internet]. 2019;50(1):18–36. Available from: https://doi.org/10.1016/j.immuni.2018.11.016
Connor DJ, Norman MA. Chapter 4 Assessment of Cognitive Status. 2014;85–117.
Morimoto K, Nakajima K. Role of the Immune System in the Development of the Central Nervous System. Front Neurosci. 2019;13(September).
Di Benedetto S, Müller L, Wenger E, Düzel S, Pawelec G. Contribution of neuroinflammation and immunity to brain aging and the mitigating effects of physical and cognitive interventions. Neurosci Biobehav Rev [Internet]. 2017;75:114–28. Available from: http://dx.doi.org/10.1016/j.neubiorev.2017.01.044
Li JT, Zhang Y. TREM2 regulates innate immunity in Alzheimer’s disease. J Neuroinflammation. 2018;15(1):1–7.
Korin B, Ben-Shaanan TL, Schiller M, Dubovik T, Azulay-Debby H, Boshnak NT, et al. High-dimensional, single-cell characterization of the brain’s immune compartment. Nat Neurosci [Internet]. 2017;20(9):1300–9. Available from: http://dx.doi.org/10.1038/nn.4610
Labzin LI, Heneka MT, Latz E. Innate Immunity and Neurodegeneration. Annu Rev Med. 2018;69(October 2017):437–49.
Wang X, Xuan W, Zhu ZY, Li Y, Zhu H, Zhu L, et al. The evolving role of neuro-immune interaction in brain repair after cerebral ischemic stroke. CNS Neurosci Ther. 2018;24(12):1100–14.
Franco Bocanegra DK, Nicoll JAR, Boche D. Innate immunity in Alzheimer’s disease: the relevance of animal models? J Neural Transm. 2018;125(5):827–46.
Da Mesquita S, Louveau A, Vaccari A, Smirnov I, Cornelison RC, Kingsmore KM, et al. Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease. Nature [Internet]. 2018;560(7717):185–91. Available from: http://dx.doi.org/10.1038/s41586-018-0368-8
Brombacher TM, Nono JK, De Gouveia KS, Makena N, Darby M, Womersley J, et al. IL-13–Mediated Regulation of Learning and Memory. J Immunol. 2017;198(7):2681–8.
Smolders SMT, Kessels S, Vangansewinkel T, Rigo JM, Legendre P, Brône B. Microglia: Brain cells on the move. Prog Neurobiol [Internet]. 2019;178. Available from: https://doi.org/10.1016/j.pneurobio.2019.04.001
Fernández de Cossío L, Guzmán A, van der Veldt S, Luheshi GN. Prenatal infection leads to ASD-like behavior and altered synaptic pruning in the mouse offspring. Brain Behav Immun. 2017;63:88–98.
Paolicelli RC, Jawaid A, Henstridge CM, Valeri A, Merlini M, Robinson JL, et al. TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss. Neuron [Internet]. 2017;95(2):297-308.e6. Available from: http://dx.doi.org/10.1016/j.neuron.2017.05.037
Salter MW, Stevens B. Microglia emerge as central players in brain disease. Nat Med [Internet]. 2017;23(9):1018–27. Available from: http://dx.doi.org/10.1038/nm.4397
Thion MS, Garel S. Microglia Under the Spotlight: Activity and Complement-Dependent Engulfment of Synapses. Trends Neurosci [Internet]. 2018;41(6):332–4. Available from: http://dx.doi.org/10.1016/j.tins.2018.03.017
Zengeler KE, Lukens JR. Innate immunity at the crossroads of healthy brain maturation and neurodevelopmental disorders. Nat Rev Immunol [Internet]. 2021;21(7):454–68. Available from: http://dx.doi.org/10.1038/s41577-020-00487-7
Connolly KJ, Kvalsvig JD. Infection, nutrition and cognitive performance in children. Parasitology. 1993;107(S1):S187–200.
Azziz-Baumgartner E, Gonzalez R, Davis W, Calvo A, Olson N, Grant L, et al. Lower cognitive scores among toddlers in birth cohorts with acute respiratory illnesses, fevers, and laboratory-confirmed influenza. Influenza Other Respi Viruses. 2022;16(1):101–12.
Ijaz MK, Rubino JR. Impact of infectious diseases on cognitive development in childhood and beyond: Potential mitigational role of hygiene. Open Infect Dis J. 2012;6(1):65–70.
Kvestad I, Taneja S, Hysing M, Kumar T, Bhandari N, Strand TA. Diarrhea, stimulation and growth predict neurodevelopment in young North Indian Children. PLoS One. 2015;10(3):1–13.
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Copyright (c) 2023 Molly Dumakuri Oktarina, Rini Sekartini, Erika Wasito, Melissa Kartjito
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