The Effect of Thiamine Supplementation for Critically Septic Patient: An Evidence-Based Case Report

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Ayu Diandra Sari
Melyarna Putri
Sheena R. Angelia
Mulianah Daya
Anak Agung Eka Widya Saraswati
Diyah Eka Andayani
Diana Sunardi

Abstract

Sepsis has been accounted for various burdens worldwide, especially in critically ill patients. This could eventually lead to inflammatory response, provocation ischemia and lactic acidosis. On the other hand, thiamine was suggested as a coenzyme which could improve the outcome of those patients. Thus, we conducted an evidence-based case study with research on PubMed, ProQuest, and Scopus using a search strategy focusing on RCT or cohort study on thiamine supplementation/level towards the outcome of critically ill patients with sepsis. We found three articles eligible for review after full-text assessment. Articles were appraised using the University of Oxford’s tools for critical appraisal. It was known that all studies were good in terms of validity and applicability. This study showed that thiamine supplementation could improve lactate clearance and reduce mortality risk, moreover, thiamine deficiency could increase the risk of lactate acidosis. However, a high level of thiamine was associated with a high level of lactate in patients with liver failure. Therefore, thiamine supplementation could be recommended for critically ill patients with sepsis and normal liver function. Further research, such as RCT or systematic review on thiamine supplementation for age groups to make this study more applicable.

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Author Biographies

Ayu Diandra Sari, Faculty of Medicine Universitas Indonesia-Dr. Cipto Mangunkusumo Hospital

Department of Nutrition

Melyarna Putri, Faculty of Medicine Universitas Indonesia-Dr. Cipto Mangunkusumo Hospital

Department of Nutrition

Sheena R. Angelia, Faculty of Medicine Universitas Indonesia-Dr. Cipto Mangunkusumo Hospital

Department of Nutrition

Mulianah Daya, Faculty of Medicine Universitas Indonesia-Dr. Cipto Mangunkusumo Hospital

Department of Nutrition

Anak Agung Eka Widya Saraswati, Faculty of Medicine Universitas Indonesia-Dr. Cipto Mangunkusumo Hospital

Department of Nutrition

Diyah Eka Andayani, Faculty of Medicine Universitas Indonesia-Dr. Cipto Mangunkusumo Hospital

Department of Nutrition

Diana Sunardi, Faculty of Medicine Universitas Indonesia-Dr. Cipto Mangunkusumo Hospital

Department of Nutrition

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